322 Results for "

Ganoderma lucidum (Leyss. Ex Fr.) Karst.

" in MedChemExpress (MCE) Product Catalog:
Products (322)

322 Results for "Ganoderma lucidum (Leyss. Ex Fr.) Karst." in MCE Product Catalog:

102
Tacrolimus
Tacrolimus
0 Images
102 Publications Verification
Cat. No.: HY-13756
CAS No.: 104987-11-3
Purity:  99.93%
Synonyms: FK506; Fujimycin; FR900506
Category:  

Infection Microorganisms Animals Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
102
Tacrolimus monohydrate
Tacrolimus monohydrate
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102 Publications Verification
Cat. No.: HY-13756A
CAS No.: 109581-93-3
Purity:  99.67%
Synonyms: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate
Category:  

Infection Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
72
Romidepsin
Romidepsin
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72 Cited Publications
Cat. No.: HY-15149
CAS No.: 128517-07-7
Purity:  99.87%
Synonyms: FK 228; FR 901228; NSC 630176
Target:  

HDAC Apoptosis

Research Areas:  

Cancer

Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively . Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .
31
5Z-7-Oxozeaenol
5Z-7-Oxozeaenol
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31 Cited Publications
Cat. No.: HY-12686
CAS No.: 253863-19-3
Purity:  99.30%
Synonyms: FR148083; L783279; LL-Z 1640-2
Category:  

Natural Products Microorganisms Monophenols Phenols Disease Research Fields Inflammation/Immunology

Target:  

MAP3K VEGFR Antibiotic

5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.
25
FR 180204
FR 180204
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25 Cited Publications
Cat. No.: HY-12275
CAS No.: 865362-74-9
Purity:  99.91%
Target:  

Flavivirus Dengue Virus ERK Apoptosis

Research Areas:  

Cancer

FR 180204 is an ATP-competitive and selective ERK inhibitor. FR 180204 inhibits ERK1 and ERK2 with IC50s of 0.51 μM (Ki=0.31 μM) and 0.33 μM (Ki=0.14 μM), respectively .
16
Kifunensine
Kifunensine
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16 Cited Publications
Cat. No.: HY-19332
CAS No.: 109944-15-2
Synonyms: FR-900494
Category:  

Alkaloids Piperidine Alkaloids Microorganisms Disease Research Fields Inflammation/Immunology

Target:  

Glycosidase

Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .
9
Cefixime
Cefixime
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9 Cited Publications
Cat. No.: HY-B1381
CAS No.: 79350-37-1
Synonyms: FR-17027; FK-027; CL-284635
Target:  

Antibiotic Bacterial

Research Areas:  

Infection Cancer

Cefixime (FR-17027) is an orally active antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .
9
Cefixime trihydrate
Cefixime trihydrate
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9 Cited Publications
Cat. No.: HY-B1381A
CAS No.: 125110-14-7
Synonyms: FR-17027 trihydrate; FK-027 trihydrate; CL-284635 trihydrate
Target:  

Antibiotic Bacterial

Research Areas:  

Infection Inflammation/Immunology Cancer

Cefixime trihydrate (FR-17027 trihydrate) is an antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections .
9
Triacsin C
Triacsin C
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9 Cited Publications
Cat. No.: HY-N6707
CAS No.: 76896-80-5
Synonyms: WS 1228A; FR 900190
Category:  

Infection Microorganisms Ketones, Aldehydes, Acids Disease Research Fields

Target:  

ACSL Family Parasite

Triacsin C (WS 1228A), is an orally active and intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, which can be isolated from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity . Triacsin C exhibits highly inhibitory effect against rotavirus replication .
8
DCP-LA
DCP-LA
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8 Cited Publications
Cat. No.: HY-108599
CAS No.: 28399-31-7
Purity:  ≥98.0%
Synonyms: FR236924
Target:  

PKC CaMK Phosphatase Apoptosis

Research Areas:  

Neurological Disease

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca( 2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis .
6
Ascomycin
Ascomycin
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6 Cited Publications
Cat. No.: HY-13557
CAS No.: 104987-12-4
Purity:  ≥98.0%
Synonyms: Immunomycin; FR-900520; FK520
Category:  

Microorganisms Neurological Disease Macrolide Antibiotics Antifungal Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:  

FKBP Parasite Fungal Antibiotic

Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .
4
FR900359
FR900359
0 Images
4 Cited Publications
Cat. No.: HY-117037
CAS No.: 107530-18-7
Purity:  99.90%
Category:  

Ardisia crenata Sims Ketones, Aldehydes, Acids Plants Myrsinaceae

Target:  

Apoptosis ERK

FR900359 is a depsipeptide selective inhibitor of Gαq/11/14 in mammalia, can inhibits ERK pathway. FR900359 suppresses the proliferation of melanoma cells and decreases of blood pressure. FR900359 also protected against airway hyperreactivity in murine models of allergen sensitization in Ovalbumin, low endotoxin (HY-W250978A)-induced sensitization model of asthma. FR900359 can be used for cancer and cardiovascular disease research .
3
Mirvetuximab soravtansine (solution)
Mirvetuximab soravtansine (solution)
0 Images
3 Cited Publications
Cat. No.: HY-132258A
CAS No.: 1453084-37-1
Purity:  99.71%
Synonyms: IMGN853 (solution)
Target:  

Antibody-Drug Conjugates (ADCs) Antifolate

Research Areas:  

Cancer

Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, and the drug-linker conjugate for ADC is sulfo-SPDB-DM4 (HY-101141). Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage .
2
FR194738
FR194738
0 Images
2 Cited Publications
Cat. No.: HY-100303A
CAS No.: 204067-52-7
Purity:  98.76%
Target:  

Squalene Monooxygenase

Research Areas:  

Metabolic Disease

FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
2
FR104
FR104
0 Images
2 Cited Publications
Cat. No.: HY-P990587

Target:  

CD28

Research Areas:  

Inflammation/Immunology

FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).
2
FR194738 free base
FR194738 free base
0 Images
2 Cited Publications
Cat. No.: HY-100303
CAS No.: 204067-45-8
Purity:  99.84%
Target:  

Squalene Monooxygenase

Research Areas:  

Metabolic Disease

FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
2
Ganoderic acid D
Ganoderic acid D
0 Images
2 Cited Publications
Cat. No.: HY-N1511
CAS No.: 108340-60-9
Category:  

Triterpenes Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Cancer

Target:  

Sirtuin Apoptosis

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells . Ganoderic acid D induces HeLa human cervical carcinoma apoptosis .
2
Fosmidomycin sodium salt
Fosmidomycin sodium salt
0 Images
2 Cited Publications
Cat. No.: HY-112853
CAS No.: 66508-37-0
Purity:  99.72%
Synonyms: FR-31564
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.
2
Bicyclomycin benzoate
Bicyclomycin benzoate
0 Images
2 Cited Publications
Cat. No.: HY-101128
CAS No.: 37134-40-0
Purity:  99.76%
Synonyms: FR2054
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium.
2
Mirvetuximab
Mirvetuximab
0 Images
2 Cited Publications
Cat. No.: HY-P99225
CAS No.: 1453084-36-0
Synonyms: M9346A

Target:  

Antifolate ADC Antibodies

Research Areas:  

Cancer

Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research .
Assay Types